HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilylacetylene → HCID 86704323, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Reactant | 5-Bromo-5'-hexyl-2,2'-bithiophene | HCID 59752457 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86704323 | HCID 86704323 | 62% |
Reaction Steps
Sonogashira cross coupling reaction was carried out using 5-bromo-5′-hexyl-2,2′-bithiophene (0.46 g, 1.39 mmol), trimethylsilyl acetylene (0.35 ml, 3.50 mmol), N-diisopropylethylamine (4.8 ml), Pd(PPh3)4 (80 mg, 0.070 mmol), CuI (13 mg, 0.070 mmol) and THF (10 ml), and the reaction was treated in accordance with a conventional method, thereby producing an intended product (yield: 62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139774B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-15232a0405ed49ada42679438c4ba935 |
| Source note | uspto-grants-2015_09 |