HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → Ethyl 2-chloro-3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | Ethyl 3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate | HCID 2760280 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Ethyl 2-chloro-3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate | HCID 86649590 | 64.3% |
Reaction Steps
Using ethyl 3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate (1.0 g, 3.8 mmol), sulfuryl chloride (620 mg, 4.9 mmol) and diethyl ether (50 mL) as starting materials and in the same manner as in Example 20-B(i), the title compound (720 mg, 64%) was obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139589B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-4e355216f0234c398a781bc98eaac04d |
| Source note | uspto-grants-2015_09 |