2-Methylpyrazolo[1,5-a]pyridine-3-carbothioamide hydrochloride → Ethyl 2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)-4-[2-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate

Participants

Reaction Steps

Using 2-methylpyrazolo[1,5-a]pyridine-3-carbothioamide hydrochloride (100 mg, 0.44 mmol) produced in Example 11-B(v), ethyl 2-chloro-3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate (250 mg, 0.85 mmol) produced above and 2-propanol (25 mL) as starting materials and in the same manner as in Example 11-B(vi), the title compound (158 mg, 84%) was obtained as a yellow solid.

Provenance & Evidence