HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → ethyl 2-chloro-3-oxo-3-(tetrahydro-2H-pyran-4-yl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | Ethyl 3-(oxan-4-yl)-3-oxopropanoate | HCID 23144053 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | ethyl 2-chloro-3-oxo-3-(tetrahydro-2H-pyran-4-yl)propanoate | HCID 86649591 | 85.2% |
Reaction Steps
Using ethyl 3-oxo-3-(tetrahydro-2H-pyran-4-yl)propanoate (1.0 g, 5.0 mmol), sulfuryl chloride (810 mg, 6.0 mmol) and diethyl ether (50 mL) as starting materials and in the same manner as in Example 20-B(i), the title compound (1.0 g, 85%) was obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139589B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-2dbf2dc192944e21832f6152148b3077 |
| Source note | uspto-grants-2015_09 |