Sulfuryl chloride → Ethyl 2-chloro-3-(2-chlorophenyl)-3-oxopropanoate

HRID 2282192Notes

Reaction equation

HRID 2282192 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:15])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11].S(Cl)([Cl:19])(=O)=O>C(OCC)C>[Cl:19][CH:9]([C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 292405Ethyl (2-chlorobenzoyl)acetate

Product 1

HCID 13593390Ethyl 2-chloro-3-(2-chlorophenyl)-3-oxopropanoateYield 85%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using ethyl 3-(2-chlorophenyl)-3-oxopropanoate (1.0 g, 5.0 mmol), sulfuryl chloride (810 mg, 6.0 mmol) and diethyl ether (50 mL) as starting materials and in the same manner as in Example 20(i), the title compound (1.0 g, 85%) was obtained as a colorless oil.

Sources & evidence

ORD record
ord-462e78a236bf45aba4ec653429f158ac
Source dataset
uspto-grants-2015_09
Patent number
US09139589B2

Reaction notes

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