1-Bromo-2-Chloroethane → HCID 53415444, compound

HRID 2282237Notes

Reaction equation

HRID 2282237 reaction equation
Cl.[F:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Br[CH2:10][CH2:11][Cl:12]>>[Cl:12][CH2:11][CH2:10][N:6]1[CH2:7][CH2:8][CH:3]([F:2])[CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 78491-Bromo-2-ChloroethaneHCID 27591584-Fluoropiperidine hydrochloride

Product 1

HCID 53415444HCID 53415444, compoundYield 21.1%

Procedure

The title compound has been prepared according to the similar manner described in 86-B (i) using 4-fluoropiperidine hydrochloride (1.00 g, 7.16 mmol) and 1-bromo-2-chloroethane (717 μL, 8.60 mmol). The crude product has been purified by silica gel column chromatography (EtOAc/hexane=10/90→40/60) to obtain pure title compound (250 mg, 21%) as a pale yellow oil.

Workup

  1. customThe crude product has been purified by silica gel column chromatography (EtOAc/hexane=10/90→40/60)

Sources & evidence

ORD record
ord-b6a81ab1e5d14f33889cd0425f720425
Source dataset
uspto-grants-2015_09
Patent number
US09139589B2

Reaction notes

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