Phenylpyruvic acid → HCID 12918242, compound

Participants

Reaction Steps

To a stirred suspension of Phenylpyruvic acid (5.0 g, 30.5 mmol) in AcOH (20 ml), was added dropwise a solution of bromine (1.57 mL, 30.5 mmol) in AcOH (5 ml) over 1 h at rt. After complete addition, stirring was continued for additional 30 min at the same temperature and then the reaction mixture was concentrated under reduced pressure. To the residue was added diisopropyl ether (30 ml) and the mixture was concentrated under reduced pressure. To the residue was added 1,2-dichloroethane (30 ml) and then the solution was kept on standing for 3 days at room temperature. The resultant precipitate was removed by filtration. To the filtrate was added hexane (20 mL) and the resulting precipitate was collected by filtration to obtain title compound (837 mg, 11%) as a colorless solid.

Provenance & Evidence