HCID 58095033, compound → HCID 58094906, compound

HRID 2282318Notes

Reaction equation

HRID 2282318 reaction equation
C([N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[C:9]1[S:10][C:11]([Sn](CCCC)(CCCC)CCCC)=[CH:12][C:13]=1[C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=1[Cl:21])C=C.FC(F)(F)S(O[C:41]1[CH:46]=[CH:45][N:44]=[C:43]2[S:47][CH:48]=[CH:49][C:42]=12)(=O)=O>>[Cl:21][C:15]1[CH:16]=[C:17]([Cl:20])[CH:18]=[CH:19][C:14]=1[C:13]1[CH:12]=[C:11]([C:41]2[CH:46]=[CH:45][N:44]=[C:43]3[S:47][CH:48]=[CH:49][C:42]=23)[S:10][C:9]=1[C:5]1[NH:4][CH:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 58095033HCID 58095033, compoundHCID 58095051HCID 58095051, compound

Product 1

HCID 58094906HCID 58094906, compound

Procedure

The title compound was prepared from 1-allyl-2-[3-(2,4-dichlorophenyl)-5-(tributylstannyl)-2-thienyl]-1H-imidazole and thieno[2,3-b]pyridin-4-yl trifluoromethanesulfonate using procedures analogous to those described in Example 8-A, Steps 2 and 3. LC/MS (AA) ES+ 428, 430. 1H NMR (400 MHz, d6 DMSO) δ: 11.97-11.69 (m, 1H), 8.73 (d, J=4.97 Hz, 1H), 8.27 (d, J=5.56 Hz, 1H), 7.88 (s, 1H), 7.77-7.73 (m, 2H), 7.68 (d, J=5.56 Hz, 1H), 7.52-7.43 (m, 2H), 7.22-6.89 (m, 2H).

Sources & evidence

ORD record
ord-f187f56ffabe4bf6b75d9ea96080b779
Source dataset
uspto-grants-2015_09
Patent number
US09139589B2

Reaction notes

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