HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2282473Generated: November 1, 2026
Diisopropylethylamine → HCID 86687057, compound
https://huagongshe.com/reaction/2282473
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,2,2-Trichloroethyl 3-tert-butyl-1-P-tolyl-1H-pyrazol-5-ylcarbamate | HCID 9931094 | — |
| Reactant | (1S,4R)-4-[3-(4-Methyl-3-triisopropylsilanyloxymethyl-piperazin-1-ylmethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-ylamine | HCID 86687056 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86687057 | HCID 86687057 | 51.1% |
Reaction Steps
A mixture of Intermediate 56e (87.0 mg, 0.15 mmol), (5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-carbamic acid 2,2,2-trichloro-ethyl ester (Synthetic Communications, 2009, 39, 3999-4009; 66.8 mg, 0.17 mmol), DIPEA (39.2 μL, 0.23 mmol) and 1,4-dioxane (2.5 mL) were heated to 60° C. for 18 h. After cooling the solvent was evaporated in vacuo and the residue purified by FCC, using 0-10% MeOH in DCM, to provide the title compound as a pale yellow foam (64 mg, 51%). LCMS (Method 3): Rt 3.63 min, m/z 834 [M+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09139584B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-cfcb9b437de3430198a46bfd5f8e9555 |
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| Source note | uspto-grants-2015_09 |
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