HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 228277Generated: October 25, 2026
Potassium Carbonate → [4-(5-Carbamoylpyrazin-2-yloxy)benzyl]phenethylcarbamic acid tert-butyl ester
https://huagongshe.com/reaction/228277
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Chloropyrazinamide | HCID 181450 | — |
| Reactant | (4-Hydroxybenzyl)phenethylcarbamic acid tert-butyl ester | HCID 59729945 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [4-(5-Carbamoylpyrazin-2-yloxy)benzyl]phenethylcarbamic acid tert-butyl ester | HCID 59730363 | 12.7% |
Reaction Steps
Take up 5-chloropyrazine-2-carboxamide (0.0527 g, 0.334 mmol), (4-hydroxybenzyl)phenethylcarbamic acid tert-butyl ester (Example 380, Part B) (0.110 g, 0.334 mmol) and K2CO3 (0.116 g, 0.836 mmol) in DMF (0.80 mL). Heat at 140° C. for 21.5 hours. Concentrate the reaction mixture then purify by flash chromatography, eluting with 50% ethyl acetate in hexanes to give the title compound (0.019 g, 12.7%):
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07560463B2 |
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| Source dataset | uspto-grants-2009_07 |
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| ORD ID | ord-4789ec0fc21247c4934dd11ac5c7e8a3 |
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| Source note | uspto-grants-2009_07 |
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