Diisopropylethylamine → HCID 89582442, compound

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Reactant	HCID 52271559	HCID 52271559	—
Reactant	N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide	HCID 86685731	—
Solvent	Dichloromethane	HCID 6344	—
Product	HCID 89582442	HCID 89582442	40.5%

Reaction Steps

According to the general procedure D, from #86 (300 mg, 0.45 mmol, 1 eq.), #168 (106 mg, 0.45 mmol, 1 eq.), dichloromethane (10 mL), HATU (194 mg, 0.54 mmol, 1.2 eq.) and diisopropylethylamine (117 mg, 0.9 mmol, 2 eq.) was synthesized the crude desired material, which was purified by reverse phase chromatography (Method P) to afford #191 (159 mg, 40%) as a white solid. HPLC (Protocol X): m/z 873.4 [M+H+], retention time=3.32 minutes (purity=99%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09138486B2
Source dataset	uspto-grants-2015_09
ORD ID	ord-3223f138d5954604a5a1ddfff1628930
Source note	uspto-grants-2015_09