HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2282912Generated: October 26, 2026
Trifluoroacetic acid → methyl (2S)-2-amino-3-(quinolin-6-yl)propanoate
https://huagongshe.com/reaction/2282912
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 6-{[(2S,5R)-3,6-dimethoxy-5-(propan-2-yl)-2,5-dihydropyrazin-2-yl]methyl}quinoline | HCID 86685769 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | methyl (2S)-2-amino-3-(quinolin-6-yl)propanoate | HCID 86685770 | — |
Reaction Steps
To a solution of #211 (7.3 g, 22.5 mmol, 1 eq.) in water (25 mL) and acetonitrile (80 mL) was added trifluoroacetic acid (9 mL) at 0° C. and the solution was stirred at 10° C. overnight. The organic layer was removed in vacuo and the remaining aqueous layer was basified to pH 9 with sodium carbonate, which was directly used for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09138486B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-434e164d28574ed5ac9977da72468d43 |
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| Source note | uspto-grants-2015_09 |
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