HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol → 3-{[3-(Diethylamino)phenyl]oxy}propyl-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol | HCID 23992385 | — |
| Edukt | 3-[(3-bromopropyl)oxy]-N,N-diethylaniline | HCID 68963374 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 3-{[3-(Diethylamino)phenyl]oxy}propyl-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide | HCID 11534358 | 63% |
Reaktionsschritte
Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0257 g, 0.0876 mmol) and 3-[(3-bromopropyl)oxy]-N,N-diethylaniline (0.0314 g, 0.110 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.032.0 g, 63.0%). EI-MS m/z 500 (M+) Rt (1.58 min).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09144571B2 |
| Quelldatensatz | uspto-grants-2015_09 |
| ORD ID | ord-834082c14f3d4cb68063222f3f42f871 |
| Quellennotiz | uspto-grants-2015_09 |