Acetic Acid → 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid

Participants

Reaction Conditions

Reaction Steps

Glacial acetic acid (5 vol. with respect to 3-cyclopropylmethoxy 4-Difluoromethoxy benzaldehyde) was taken in a vessel and to this mixture of 3-cyclopropylmethoxy 4-Difluoromethoxy benzaldehyde and sulfamic acid (1.35 eq with respect to 3-cyclopropylmethoxy 4-Difluoromethoxy benzaldehyde) was added. The reaction mass was cooled to 5-10° C. under stirring. In another clean reaction vessel sodium chlorite (1.63 eq) was taken in water (1.5 vol. with respect to 3-cyclopropylmethoxy 4-Difluoromethoxy benzaldehyde) and added dropwise to the above prepared reaction solution at temperature below 10° C. The reaction mixture was stirred for 1 hr at 5-10° C. After completion of the reaction, water was added to get a white slurry. The solid was filtered and washed with water and dried under vacuum at 45-50° C. to get 3-cyclopropylmethoxy 4-Difluoromethoxy benzoic acid.

Provenance & Evidence