HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → (4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | (2S,1R)-2-Amino-3-fluoro-1-(4-iodo-phenyl)-propan-1-ol | HCID 45257860 | — |
| Product | (4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine | HCID 86695412 | — |
Reaction Steps
Commercially available (1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol (6.0 g, 20.0 mmol) is dissolved in acetone (150 mL) and the mixture stirred at room temperature for 16 hours. The solvent is removed under reduced pressure to give the title compound (7.0 g). m/z (Cl) M+H 295.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09145355B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-9d520630afda4a13ba55bf85eb6b87e3 |
| Source note | uspto-grants-2015_09 |