Potassium Carbonate → HCID 86302075, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(2-bromo-5-methoxyphenyl)-2-methylbutan-1-one (0.1 g, 3.68 mmol) in DMSO, were added L-proline (8.49 mg, 0.73 mmol), K2CO3 (76.42 mg, 5.53 mmol), CuSO4:5H2O (14.61 mg, 0.73 mmol), sodium ascorbate (14.61 mg, 0.73 mmol), and NaN3 (28.77 mg, 4.42 mmol). The mixture was stirred for 17 h at 70° C. (oil bath temperature). The reaction mixture was diluted with 30 mL of water and extracted with ethyl acetate (3×30 mL). Combined organic layer was dried (Na2SO4) and evaporated under reduced pressure. The crude was purified over silica gel (ethyl acetate and pet ether as eluent) to procure 2g (0.053 g, 2.58 mmol) in 69% yields.

Provenance & Evidence