HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 5-(Acetylamino)-2,4-dichlorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 5-amino-2,4-dichlorobenzoic acid | HCID 5200245 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-(Acetylamino)-2,4-dichlorobenzoic acid | HCID 283316 | 96% |
Reaction Steps
Acetic anhydride (27 mL) was added to 2,4-dichloro-5-aminobenzoic Acid 1-3 (8.0 g, 0.041 mol) in glacial AcOH (150 mL). The solution was stirred at room temperature for 30 min and concentrated to yield the desired acetamide 1-4 as a white solid (9.6 g, 96%). 1H NMR (400 MHz, CD3OD) δ2.19 (s, 3H), 7.62 (s, 1H), 8.32 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09145375B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-e80f96cc675c4aa2b76c3bea0434b825 |
| Source note | uspto-grants-2015_09 |