p-Toluenesulfonic acid → HCID 69673612, compound

Participants

Reaction Steps

To a solution of 2-(2-(3,5-diphenylpyridazin-4-yl)oxazol-4-yl)propan-2-ol (80 mg, 0.22 mmol) in toluene (4 mL), p-toluenesulfonic acid (20 mg) was added and the reaction mixture was refluxed for 2 h. After completion of starting material, reaction was quenched with solid K2CO3. Solvent was removed under reduced pressure to obtain the crude product that was purified by column chromatography (100-200 mesh silica gel, 20% EtOAc-Hexane) to furnish 2-(3, 5-diphenylpyridazin-4-yl)-4-vinyloxazole (70 mg, 92%) as a gummy liquid.

Provenance & Evidence