HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminobenzenesulfonamide → 2-[[(E)-2-(4-Benzofuran-2-ylphenyl)ethenyl]sulfonylamino]benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminobenzenesulfonamide | HCID 72894 | — |
| Reactant | (E)-2-(4-benzofuran-2-ylphenyl)ethenesulfonyl chloride | HCID 86632000 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-[[(E)-2-(4-Benzofuran-2-ylphenyl)ethenyl]sulfonylamino]benzenesulfonamide | HCID 86631999 | 46% |
Reaction Steps
2-Aminobenzenesulfonamide (38 mg, 0.22 mmol) was dissolved in pyridine (2 ml), (E)-2-(4-benzofuran-2-ylphenyl)ethenesulfonyl chloride (70 mg, 0.22 mmol) was added and the mixture stirred for 2 h. The solvent was removed in vacuo and the residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (46 mg, 46%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09145380B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-f98fc5ad86e74249a4e08ca6fe18454e |
| Source note | uspto-grants-2015_09 |