Methanol → HCID 42645776, compound

Participants

Reaction Steps

2-[[(E)-2-[4-(2-Furyl)phenyl]ethenyl]sulfonylamino]benzenesulfonamide (Example 18) (140 mg, 0.35 mmol) was dissolved in ethyl acetate (1.5 mL) and methanol (1.5 mL) and the mixture was subjected to reduction using the H-cube instrument. The reaction mixture was eluted through the Pd/C (10%) cartridge using full hydrogen (1 atm) at 0.5 ml/min. The solvent was then removed and the crude material was purified on semi-preparative HPLC using an X-Terra column to give the title compound (18 mg, 13%) as a white solid. The compound of Example 17 was also obtained.

Provenance & Evidence