反应详情

温度

105 °C

A mixture of 7-methyl-1,1-dioxo-1,4-dihydro-2-H-benzo[1,2,4]thiadiazin-3-one (7.20 g, 36.36 mmol) in aqueous H2SO4 (50% v/v, 200 mL) was heated at 105° C. for 16 h. The clear solution was then cooled to 0° C. and neutralized using 5N NaOH. The product was extracted with ethyl acetate. The combined extracts were washed with water and concentrated under reduced pressure. The crude product was purified by flash column chromatography using ethyl acetate/hexane (1:1) to afford 4.5 g (85%) of the title compound.

1. temperatureThe clear solution was then cooled to 0° C.
2. extractionThe product was extracted with ethyl acetate
3. washThe combined extracts were washed with water
4. concentrationconcentrated under reduced pressure
5. customThe crude product was purified by flash column chromatography