HCID 42643899, compound → HCID 42643898, compound

HRID 2283281Notes

Reaction equation

HRID 2283281 reaction equation
[C:1]1(/[CH:7]=[CH:8]/[S:9]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[S:19]([NH2:22])(=[O:21])=[O:20])(=[O:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>CO.[Pd]>[CH2:8]([S:9]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[S:19]([NH2:22])(=[O:20])=[O:21])(=[O:10])=[O:11])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 42643899HCID 42643899, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 42643898HCID 42643898, compoundYield 8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-[[(E)-2-Phenylethenyl]sulfonylamino]benzenesulfonamide (0.052 g, 0.15 mmol) was dissolved in MeOH (5 mL) followed by the addition of 10% Pd/C (30 mg). The solution was subjected to hydrogen overnight at 40° C. After filtration, the crude product was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (4 mg, 8%) as a white solid.

Workup

  1. filtrationAfter filtration
  2. customthe crude product was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer)

Sources & evidence

ORD record
ord-fd68800113544ab7a368a950f4c4da80
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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