Sodium Carbonate → HCID 57751016, compound

Participants

Reaction Conditions

Reaction Steps

Tetrakis(triphenylphosphine)palladium(0) (14 mg, 0.012 mmol) was added to 2,5-dichlorophenylboronic acid (57 mg, 0.30 mmol) in DMF (0.25 mL) and a DMF stock solution of 0.5M 2-[(3-bromophenyl)sulfonylamino]benzenesulfonamide (0.5 mL, 0.25 mmol). The reaction mixture was stirred at RT under argon for 15 minutes before addition of 2M Na2CO3 (0.5 mL). The reaction was stirred overnight at 90° C., filtered and purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (15 mg, 13%) as a white solid.

Provenance & Evidence