2,3-Difluorobenzene-1-sulfonyl chloride → HCID 57751038, compound

HRID 2283293Notes

Reaction equation

HRID 2283293 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].[F:13][C:14]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=1[S:21](Cl)(=[O:23])=[O:22]>N1C=CC=CC=1>[F:13][C:14]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=1[S:21]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[S:9](=[O:11])(=[O:10])[NH2:12])(=[O:23])=[O:22]

Participants

4

Reactant 2

HCID 218690652,3-Difluorobenzene-1-sulfonyl chlorideHCID 224818252-Amino-5-fluorobenzene-1-sulfonamide

Product 1

HCID 57751038HCID 57751038, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-Amino-5-fluorobenzenesulfonamide (29 mg, 0.15 mmol) was dissolved in pyridine (1 ml) and 2,3-difluorophenylsulfonyl chloride (19 μl, 0.15 mmol) was added and the reaction stirred overnight. The solvent was removed in vacuo and the residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (25 mg, 46%).

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer)

Sources & evidence

ORD record
ord-90068a253ac7493f8ac7190cdebc4c47
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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