Potassium Phosphate, Tribasic → HCID 68781555, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(3-bromophenylsulfonamido)-5-phenoxybenzenesulfonamide (Example 155a) (150.0 mg, 0.31 mmol), 3-(trifluoromethoxy)benzeneboronic acid (192 mg, 0.93 mmol), tricyclohexyl phosphine (25 mg, 0.09 mmol) and potassium phosphate (131 mg, 0.62 mmol) in DMF (10 mL), was added Pd(OAc)2 (14 mg, 0.06 mmol). The reaction mixture was stirred at 80° C. overnight, diluted with 1N HCl and the product was extracted with ethyl acetate. The organic phase was separated, dried over sodium sulfate and concentrated in vacuo. The crude product was purified by flash column chromatography using methanol/DCM (1:99) to afford the title compound (92 mg, 53%).

Provenance & Evidence