2,3-Dichlorobenzene-1-sulfonyl chloride → HCID 68779175, compound

Participants

Reaction Steps

To a solution of 2-amino-5-methoxy-benzenesulfonamide (2.73 g, 13.43 mmol) in pyridine (25 mL), 2,3-dichlorobenzenesulfonyl chloride (3.68 g, 15.0 mmol) was added slowly at 0° C. The reaction mixture was stirred at RT overnight and then concentrated under reduced pressure. The residue was then partitioned between ethyl acetate and 1N HCl. The organic layer was separated, dried over sodium sulfate and concentrated in vacuo. The crude product was purified by flash column chromatography using ethyl acetate/hexane (1:1) to afford the title compound (4.8 g, 87%).

Provenance & Evidence