2-Aminobenzenesulfonamide → HCID 47337178, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-aminobenzenesulfonamide (172 mg) in pyridine (3 ml) was added 5-chlorothiophene-2-sulfonyl chloride (217 mg) and the resulting mixture was heated at 60° C. for 18 h. The mixture was concentrated and then partitioned between DCM (20 ml) and 2N HCl (10 ml). The organics were separated, dried (MgSO4) and evaporated to a gum which was purified by silica chromatography eluting with a gradient of ethyl acetate/hexane to give the title compound as a solid (201 mg).

Provenance & Evidence