m-Bromobenzenesulphonyl chloride → HCID 57751032, compound

HRID 2283324Notes

Reaction equation

HRID 2283324 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[Br:12][C:13]1[CH:14]=[C:15]([S:19](Cl)(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1>C(OCC)C>[Br:12][C:13]1[CH:14]=[C:15]([S:19]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[S:8](=[O:9])(=[O:10])[NH2:11])(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 17943m-Bromobenzenesulphonyl chlorideHCID 728942-Aminobenzenesulfonamide

Product 1

HCID 57751032HCID 57751032, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound was synthesized as described for Example 178 in 48% yield, starting from 2-aminobenzenesulfonamide and 3-bromobenzenesulfonyl chloride. The product solidified after the extractive work up. Diethyl ether (25 mL) was added and the crystals were crushed with a glass stick. The mixture was filtered and the solid was rinsed with diethyl ether and dried in vacuo at ambient temperature.

Workup

  1. customthe crystals were crushed with a glass stick
  2. filtrationThe mixture was filtered
  3. washthe solid was rinsed with diethyl ether
  4. customdried in vacuo at ambient temperature

Sources & evidence

ORD record
ord-530f2fd906f049bd85bcd615e7dd4551
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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