HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2283346Generated: November 1, 2026
1,2-Dimethoxyethane → (E)-N,N-Diallyl-4-(2-(4-(benzofuran-2-yl)phenyl)vinylsulfonamido)pyridine-3-sulfonamide
https://huagongshe.com/reaction/2283346
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Benzo[b]furan-2-boronic acid | HCID 2776266 | — |
| Reactant | (E)-N,N-diallyl-4-(2-(4-bromophenyl)vinylsulfonamido)pyridine-3-sulfonamide | HCID 57751063 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Product | (E)-N,N-Diallyl-4-(2-(4-(benzofuran-2-yl)phenyl)vinylsulfonamido)pyridine-3-sulfonamide | HCID 57751062 | 38% |
Reaction Steps
A mixture of (E)-N,N-diallyl-4-(2-(4-bromophenyl)vinylsulfonamido)pyridine-3-sulfonamide (0.47 g, 0.94 mmol), 2-benzofuranboronic acid (0.20 g, 1.23 mmol), (1,1′-bis(diphenylphosphino)ferrocene)-dichloropalladium(II) (0.039 g, 0.050 mmol), cesium carbonate (0.46 g, 1.41 mmol), 1,2-dimethoxyethane (9 mL) and water (1 mL) under an atmosphere of argon was heated at 120° C. for 15 min in a microwave. The reaction mixture was partitioned between ethyl acetate and diluted hydrochloric acid, the organic phase was dried over magnesium sulfate and the solvent was evaporated. Purification by column chromatography, using chloroform/methanol (98:2) as the eluent, gave the title compound in 38% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09145380B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-dac5a752ba8244489d61bc0f2f0a4de4 |
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| Source note | uspto-grants-2015_09 |
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