Methanol → HCID 57750991, compound

HRID 2283360Notes

Reaction equation

HRID 2283360 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][S:10]([NH:13][C:14]2[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][C:15]=2[S:23](=[O:26])(=[O:25])[NH2:24])(=[O:12])=[O:11])=[C:4]([O:27][CH3:28])[CH:3]=1.[CH3:29]O>S(Cl)(Cl)=O>[CH3:29][O:19][C:18](=[O:20])[C:17]1[CH:21]=[CH:22][C:14]([NH:13][S:10]([CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=2[O:27][CH3:28])(=[O:12])=[O:11])=[C:15]([S:23](=[O:25])(=[O:26])[NH2:24])[CH:16]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 57750922HCID 57750922, compound

Product 1

HCID 57750991HCID 57750991, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

To a solution of 4-[2-(4-chloro-2-methoxy-phenyl)-ethanesulfonylamino]-3-sulfamoyl-benzoic acid (0.18 g, 0.40 mmol) in anhydrous methanol (15 mL), thionyl chloride (1 mL) was added and the mixture was heated at reflux for 18 hours. The volatiles were removed under reduced pressure to give 0.18 g (97% yield) of the title compound.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 18 hours
  3. customThe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-4313205546344ba1a7c5064f8c2013b6
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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