m-Bromobenzenesulphonyl chloride → HCID 57750916, compound

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Reaction Steps

A mixture of 3-amino-thiophene-2-sulfonic acid amide (100 mg, 0.56 mmol) and 3-bromo-benzenesulfonyl chloride (97 μL, 0.67 mmol) in anhydrous pyridine (3 mL) was stirred at room temperature for 17 hours. The solvent was removed in vacuo and the residue was taken up in dichloromethane (25 mL). The organic phase was washed with 1 M hydrochloric acid, saturated sodium bicarbonate and brine, dried over sodium sulfate and concentrated under reduced pressure. Purification by column chromatography, using 4-6% methanol in dichloromethane as the eluent, gave 147.6 mg (66% yield) of the title compound.

Provenance & Evidence