P-Toluenesulfonylhydrazide → HCID 57751061, compound

Participants

Reaction Conditions

Reaction Steps

(E)-4-Chloro-2-(2-(4-(difluoromethoxy)phenyl)vinylsulfonamido)benzenesulfonamide (0.426 g, 0.97 mmol) was dissolved in anhydrous tetrahydrofuran (2 mL). Sodium acetate (0.318 g, 3.88 mmol) and p-toluenesulfonic acid hydrazide (0.723 g, 3.88 mmol) were added and the reaction was heated in a microwave at 180° C. for 60 min. The mixture was filtered and the solvent was evaporated under vacuum. Purification by preparative HPLC, gave 41 mg (10% yield) of the title compound.

Provenance & Evidence