Triethylamine → 2,3-Dichloro-N-(4-fluoro-5-methoxy-2-sulfamoylphenyl)benzenesulfonamide

Participants

Reaction Steps

2-Amino-5-fluoro-4-methoxybenzenesulfonamide (200 mg, 0.91 mmol) and 2,3-dichlorobenzene-1-sulfonyl chloride (290 mg, 1.18 mmol) were dissolved in anhydrous dichloromethane (5 mL). Anhydrous triethylamine (0.290 mL, 2.09 mmol) was added and the reaction was stirred at room temperature for 48 hours under an inert atmosphere. The reaction was quenched using 2 M hydrochloric acid (20 mL) and was extracted with dichloromethane. The combined organic phase were washed with water, dried over magnesium sulfate and concentrated under vacuum. Purification by preparative HPLC gave 23 mg (6% yield) of the title compound.

Provenance & Evidence