(E)-2-(3,4-dichlorophenyl)ethenesulfonyl chloride → (E)-5-Chloro-2-(2-(3,4-dichlorophenyl)vinylsulfonamido)-4-fluoro benzenesulfonamide

HRID 2283377Notes

Reaction equation

HRID 2283377 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([Cl:9])=[CH:4][C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].[Cl:14][C:15]1[CH:16]=[C:17](/[CH:22]=[CH:23]/[S:24](Cl)(=[O:26])=[O:25])[CH:18]=[CH:19][C:20]=1[Cl:21]>>[Cl:9][C:5]1[C:6]([F:8])=[CH:7][C:2]([NH:1][S:24](/[CH:23]=[CH:22]/[C:17]2[CH:18]=[CH:19][C:20]([Cl:21])=[C:15]([Cl:14])[CH:16]=2)(=[O:26])=[O:25])=[C:3]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:4]=1

Participants

3

Reactant 2

HCID 22719686(E)-2-(3,4-dichlorophenyl)ethenesulfonyl chlorideHCID 231042282-Amino-5-chloro-4-fluorobenzenesulfonamide

Product 1

HCID 57751073(E)-5-Chloro-2-(2-(3,4-dichlorophenyl)vinylsulfonamido)-4-fluoro benzenesulfonamideYield 40%

Procedure

The title compound was synthesized as described for Example 226 a) in 40% yield, starting from 2-amino-5-chloro-4-fluorobenzenesulfonamide and (E)-2-(3,4-dichlorophenyl)ethenesulfonyl chloride.

Sources & evidence

ORD record
ord-92a7f699cf22425ea2961bb2572a91ca
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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