HCID 57750974, compound → HCID 57751106, compound

HRID 2283379Notes

Reaction equation

HRID 2283379 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[S:11]([NH:14][C:15]2[CH:23]=[CH:22][C:21]3[CH2:20][CH2:19][CH2:18][C:17]=3[C:16]=2[S:24]([NH2:27])(=[O:26])=[O:25])(=[O:13])=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8].ClC1C=C(/C=C/S(NC2C=C3C(CCC3)=CC=2S(N)(=O)=O)(=O)=O)C=CC=1Cl>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][S:11]([NH:14][C:15]2[CH:23]=[CH:22][C:21]3[CH2:20][CH2:19][CH2:18][C:17]=3[C:16]=2[S:24]([NH2:27])(=[O:26])=[O:25])(=[O:13])=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 57750974HCID 57750974, compoundHCID 57751045HCID 57751045, compound

Product 1

HCID 57751106HCID 57751106, compoundYield 20%

Procedure

The title compound was synthesized as described for Example 226 in 20% yield, starting from a mixture of (E)-5-(2-(3,4-dichlorophenyl)vinylsulfonamido)-2,3-dihydro-1H-indene-4-sulfonamide compound and (E)-6-(2-(3,4-dichlorophenyl)vinylsulfonamido)-2,3-dihydro-1H-indene-5-sulfonamide (1:1). Purification by preparative HPLC.

Workup

  1. customPurification by preparative HPLC

Sources & evidence

ORD record
ord-074dcb4653584322bb54deedd4059d2b
Source dataset
uspto-grants-2015_09
Patent number
US09145380B2

Reaction notes

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