Hydrochloric Acid → HCID 89544538, compound

Participants

Reaction Steps

Step 3 To a solution of {(R)-1-[3-(6-amino-pyridine-3-carbonyl)-4-chloro-2-fluoro-phenyl]-propyl}-carbamic acid tert-butyl ester (2.18 g, 4.43 mmol) in DCM (50 mL) was added 4M HCl in dioxane (7.75 mL, 31 mmol, 7 eq) and the reaction stirred for 18 h. Complete conversion. Mixture was concentrated and then triturated with diethyl ether (50 mL) and the solid filtered off and dried in a vacuum oven to give [3-((R)-1-amino-propyl)-6-chloro-2-fluoro-phenyl]-(6-amino-pyridin-3-yl)-methanone (1.54 g, 4.35 mmol, 98%) as a beige solid and the HCl salt

Provenance & Evidence