HCID 89544689, compound → HCID 89545056, compound

Participants

Reaction Steps

Step 2 Tert-butyl N-[(1R)-1-{4-chloro-2-fluoro-3-[(6-methoxypyridin-3-yl)carbonyl]phenyl}-propyl]carbamate (90.0 mg, 0.21 mmol) was dissolved in 6M HCl in water (5.0 mL) and the reaction was heated at reflux for 8 h. Complete conversion. Mixture was quenched with NaOH (5M) until pH˜5, then extracted with 4:1 CHCl3:IPA (3×20 mL). Combined organic extracts were dried (Na2SO4), filtered and concentrated in vacuo to give 5-({3-[(1R)-1-aminopropyl]-6-chloro-2-fluorophenyl}carbonyl)-1,2-dihydropyridin-2-one (56.2 mg, 88% yield).

Provenance & Evidence