HCID 117874814, compound → {1-[5-({3-[(1R)-1-aminopropyl]-6-chloro-2-fluorophenyl}carbonyl)pyridin-2-yl]-1H-pyrazol-4-yl}methanol

Participants

Reaction Conditions

Reaction Steps

To ethyl 1-[5-({3-[(1R)-1-aminopropyl]-6-chloro-2-fluorophenyl}carbonyl)pyridin-2-yl]-1H-pyrazole-4-carboxylate (Example 41) (0.154 g, 0.358 mmol) in THF (4 ml) at 0° C. was added 1M DiBAL-H/THF (0.78 ml, 0.787 mmol) stirred at 0° C. for 15 minutes allowed to warm to ambient, further 1M DiBAL-H/THF (0.78 ml, 0.787 mmol) added left further 30 minutes at ambient. Reaction quenched with Rochelles salt and extracted with EtOAc. The organic phase was dried (Na2SO4), filtered and concentrated, purified by Prep HPLC to give {1-[5-({3-[(1R)-1-aminopropyl]-6-chloro-2-fluorophenyl}carbonyl)pyridin-2-yl]-1H-pyrazol-4-yl}methanol (0.015 g).

Provenance & Evidence