HCID 89544762, compound → HCID 89544746, compound

Participants

Reaction Steps

Step 2 ((R)-1-{3-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-benzoyl]-4-chloro-2-fluoro-phenyl}-propyl)-carbamic acid tert-butyl ester was deprotected as Step 2 in the preparation of Example 2. A mixture of the doubly deprotected product [3-((R)-1-amino-propyl)-6-chloro-2-fluoro-phenyl]-(4-hydroxymethyl-phenyl)-methanone (=Example 50) and the trans-esterified product acetic acid 4-[3-((R)-1-amino-propyl)-6-chloro-2-fluoro-benzoyl]-benzyl ester (=Example 49) was obtained. Separation was achieved by column chromatography with 0-8% ammonia in methanol/dichloromethane.

Provenance & Evidence