Hydrochloric Acid → HCID 89544628, compound

Participants

Reaction Steps

Step 2 To a solution of 3-[3-((R)-1-tert-Butoxycarbonylamino-propyl)-6-chloro-2-fluoro-benzoyl]-benzoic acid tert-butyl ester (219 mg, 0.45 mmol) in DCM (5 mL) was added 4M HCl in dioxane (0.445 mL, 1.78 mmol, 4 eq) and the reaction stirred for 18 h. Complete conversion. Mixture was concentrated and then triturated with diethyl ether (˜1 mL) and the solid filtered off to give 3-[3-((R)-1-amino-propyl)-6-chloro-2-fluoro-benzoyl]-benzoic acid (154 mg, 0.41 mmol, 92%). [M+H]+ 336

Provenance & Evidence