Hydrochloric Acid → HCID 89544879, compound

Participants

Reaction Steps

Step 3 tert-Butyl N—[(R)-{3-[(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)carbonyl]-4-chloro-2-fluorophenyl}(cyclopropyl)methyl]carbamate (265 mg, 0.48 mmol) was treated with a 4M hydrogen chloride solution in 1,4-dioxane (5 ml) at room temperature for 60 minutes. Material that had precipitated out was re-dissolved by the addition of methanol before the mixture was concentrated in vacuo. The residue was re-concentrated from methanol before the addition of a small amount of ethyl acetate and diethyl ether to elicit precipitation. The solids were collected by filtration and were dried in a vacuum oven furnishing [4-({3-[(R)-amino(cyclopropyl)methyl]-6-chloro-2-fluorophenyl}carbonyl)phenyl]methanol hydrochloride as a white solid (138 mg)

Provenance & Evidence