Hydrochloric Acid → HCID 89544869, compound

Participants

Reaction Steps

Step 5 {(R)-1-[3-(3-Cyano-benzoyl)-2-fluoro-4-methoxy-phenyl]-propyl}-carbamic acid tert-butyl ester (200 mg) was dissolved in DCM (5 mL), 4M HCl in dioxane (485 uL, 1.94 mmol, 4 eq) was added and the reaction mixture was stirred for 5 hours. Water was then added and the mixture was made basic with 1M NaOH. The organic phase was isolated by phase separator and combined and concentrated to give 3-[3-((R)-1-amino-propyl)-2-fluoro-6-methoxy-benzoyl]-benzonitrile.

Provenance & Evidence