Potassium Carbonate → HCID 89544992, compound

Participants

Reaction Steps

To (3S)-3-{[(1R)-1-{4-chloro-3-[(4-cyanophenyl)carbonyl]-2-fluorophenyl}propyl]amino}-butanamide (compound of Example 91) (0.016 g, 0.04 mmol) added DMSO (1 ml) treated with K2CO3 (0.027 g, 0.2 mmol) stirred ambient for 2 hours, further K2CO3 (0.027 g, 0.2 mmol) added left stirring ambient for 16 hours. Reaction purified by Prep HPLC to give 4-({3-[(1R)-1-{[(2S)-1-carbamoylpropan-2-yl]amino}propyl]-6-chloro-2-fluorophenyl}carbonyl)-benzamide (1 mg).

Provenance & Evidence