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HRID2283424

反应详情

EQUATION

反应方程式

HRID 2283424 的结构方程式

REACTANTS

反应物

2
结构：NC(=O)CCBr
HCID233589

3-Bromopropanamide

C3H6BrNO

结构：CC[C@@H](N)c1ccc(Cl)c(C(=O)c2cccnc2)c1F
HCID89544767

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@@H](NCCC(N)=O)c1ccc(Cl)c(C(=O)c2cccnc2)c1F
HCID89544828

未命名化合物

收率 0.8%

PROCEDURE

实验过程

(1R)-1-{4-chloro-2-fluoro-3-[(pyridin-3-yl)carbonyl]phenyl}propan-1-amine (0.1 g, 0.34 mmol) and 3-bromopropionamide (0.052 g, 0.34 mmol) heated in a microwave tube at 120° C., 150 W for 30 minutes. Reaction purified by Prep HPLC using Basic 0A3 system, followed by silica column (Biotage SP4) eluting 0-10% MeOH in EtOAc to give 3-{[(1R)-1-{4-chloro-2-fluoro-3-[(pyridin-3-yl)carbonyl]phenyl}propyl]amino}propanamide (0.001 g).

WORKUP

后处理

  1. customReaction
  2. custompurified by Prep HPLC
  3. washeluting 0-10% MeOH in EtOAc