Ethanol → HCID 89545057, compound

Participants

Reaction Steps

To (6-Chloro-2-fluoro-3-{(R)-1-[(3-trityl-3H-imidazol-4-ylmethyl)-amino]-propyl}-phenyl)-pyridin-3-yl-methanone (0.208 g, 0.33 mmol) suspended in acetone (2 ml) treated with saturated HCl/EtOAc, ethanol added till all in solution stirred at ambient for 18 hours, concentrated then purified by Prep HPLC to give [(1R)-1-{4-chloro-2-fluoro-3-[(pyridin-3-yl)carbonyl]phenyl}propyl](1H-imidazol-5-ylmethyl)amine (0.07 g), MS: [M+H] 373

Provenance & Evidence