Hydrochloric Acid → HCID 89544881, compound

Participants

Reaction Steps

To a solution of tert-butyl 3-{[(1S)-1-{4-chloro-2-fluoro-3-[(pyridin-3-yl)carbonyl]phenyl}-propyl]carbamoyl}piperidine-1-carboxylate (220 mg, 0.44 mmol) in DCM (3 mL) was added 4M HCl in dioxane (0.44 mL, 1.75 mmol, 4 eq) and the reaction stirred for 18 h. The mixture was concentrated and then triturated with diethyl ether (˜5 mL) and the pale green solid filtered off and dried in a vacuum oven to give N-[(1S)-1-{4-chloro-2-fluoro-3-[(pyridin-3-yl)carbonyl]phenyl}propyl]piperidine-3-carboxamide as a white solid (80.0 mg).

Provenance & Evidence