ethyl {3-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenyl}acetate → ethyl [3-(1H-pyrazol-4-yl)phenyl]acetate

HRID 2283493Notes

Reaction equation

HRID 2283493 reaction equation
O1CCCCC1[N:7]1[CH:11]=[C:10]([C:12]2[CH:13]=[C:14]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:15]=[CH:16][CH:17]=2)[CH:9]=[N:8]1>CO.Cl>[NH:7]1[CH:11]=[C:10]([C:12]2[CH:13]=[C:14]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:15]=[CH:16][CH:17]=2)[CH:9]=[N:8]1

Participants

3

Reactant 1

HCID 86731997ethyl {3-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenyl}acetate

Product 1

HCID 86731998ethyl [3-(1H-pyrazol-4-yl)phenyl]acetate

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

A mixture of ethyl {3-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenyl}acetate (160 g, 0.50 mol) in MeOH/HCl (800 mL) was stirred at room temperature for 3 hours. The mixture was concentrated under reduced pressure and washed with Et2O (300 mL) to afford ethyl [3-(1H-pyrazol-4-yl)phenyl]acetate as a solid.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. washwashed with Et2O (300 mL)

Sources & evidence

ORD record
ord-25912a9e4c5f458888f7df3b4240375b
Source dataset
uspto-grants-2015_09
Patent number
US09145391B2

Reaction notes

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