p-Toluenesulfonic acid monohydrate → HCID 86682358, compound

Participants

Reaction Steps

A solution of p-toluenesulfonic acid monohydrate (0.851 g, 4.41 mmol) in acetone (10 mL) was added to a solution of 5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide (2.42 g, 4.41 mmol) in acetone (15 mL). After stirring at ambient temperature for 15 minutes, the reaction mixture was concentrated in vacuo. The residue was suspended in diethyl ether (75 mL) and stirred for 2 hours. The resulting solid was collected by filtration, dried, and then recrystallized from ethyl acetate-heptane-methanol (20:10:1) to afford the title compound as a tan crystalline solid (1.78 g, 56%).

Provenance & Evidence