Potassium Carbonate → HCID 56599016, compound

Participants

Reaction Conditions

Reaction Steps

2-(3-Methylpyridazin-4-yl)-4-(trifluoromethyl)phenol (Preparation 44, 100 mg, 0.38 mmol) and 3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (Preparation 39, 108 mg, 0.38 mmol) were dissolved in dimethylsulfoxide (2 mL). Potassium carbonate (157 mg, 1.14 mmol) was added and the reaction mixture was heated to 90° C. for 4 hours. The reaction mixture was cooled and the crude material purified by reverse phase column chromatography (ISCO™ Companion, C18 silica, 5% to 60% acetonitrile in water gradient elution) to afford the title compound as an off-white solid (130 mg).

Provenance & Evidence