Trifluoroacetic acid → HCID 86682368, compound

Participants

Reaction Steps

tert-Butyl 4-[4-(5-chloro-2-hydroxyphenyl)pyrimidin-2-yl]piperazine-1-carboxylate (Preparation 2, 48.6 mg, 0.11 mmol), tert-butyl 1,3-thiazol-4-yl[(2,4,5-trifluorophenyl)sulfonyl]carbamate (Preparation 45, 41.9 mg, 0.11 mmol) and potassium carbonate (21.9 mg, 0.16 mmol) were mixed in dimethylsulfoxide (1 mL) and shaken at ambient temperature for 18 hours. The reaction was diluted with water and the precipitate collected by filtration. The solid was dissolved in dichloromethane (2 mL), and dried over anhydrous magnesium sulfate. The mixture was filtered and trifluoroacetic acid (0.06 mL, 0.78 mmol) was added to the filtrate. After 2 hours the reaction was concentrated in-vacuo and purified by reverse phase HPLC to afford the title compound as a tan glass (52 mg).

Provenance & Evidence